Its broad usefulness in the repairing of damage caused by free radicals explains why its also referred to as the master antioxidant
Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position 7007 of the FPN1 promoter
Additionally, the lncRNA LIPE-AS1 is highly expressed in PCOS follicular fluid EVs and modulates steroid metabolism, granulosa cell proliferation, and apoptosis through the LIPE-AS1/miR-4306/LHCGR axis, contributing to poor oocyte quality and impaired embryo development (Yu et al., 2024)
The more efficient conjugation of the QIs to GSH may have reduced covalent modification of cellular macromolecules, like ER proteins Grp78/Bip (Xu et al., 2015), microsomal GST (Weis et al., 1992), and PDI ( Although reactive QI formation has been associated with AQ-induced (cyto)toxicity in vitro (Naisbitt et al., 1998